Niclosamide is an active chlorinated salicylanilide compound, with anthelmintic and potential antineoplastic activity used to treat tapeworm infections but has a broad spectrum of therapeutic potential. Scientists are investigating niclosamide and how it inhibits CoV replication and viral antigen synthesis by investigating the various mode of actions such as regulating the mTORC1 pathway, members of which may be interacting with SARS-CoV-2 N and Orf8 proteins; and reducing replication of related coronavirus MERS-CoV via SKP2 inhibition.