Cytokine and Chemokine Responses Study in Animal Models of SARS-CoV-2 Infection

As an expert in the field of drug discovery, Creative Biolabs is helping our customers with various drug discovery services targeting SARS-CoV-2 infection diseases. Based on our deep analytical capabilities and vast experience in virus studies, our client-focused, integrated team will anticipate challenges, overcome difficulties and provide custom SARS-CoV-2 preclinical studies with numerous assays. We guarantee the finest results for our customers all over the world.

Introduction to the Animal Models

Nowadays, the large-scale spread of SARS-CoV-2 in humans has put global public health institutions on high alert. Many companies and groups are dedicated to developing novel drugs for treating SARS-CoV-2 infection in clinical use. Previous studies have demonstrated that animal models for virus-related diseases are effective tools used in the evaluation of disease activity and in the detection of mechanisms and factors responsible for the disease progress. These results collected from different models can provide meaningful information for assessing the safety of candidate drugs in clinical use. Meanwhile, a number of methods have been developed for studying mutant strains of mice and transgenic mice to exhibit all the immunological properties of disease pathogens. In addition, the chemokine profile and response to cytokine inhibition in animal models are also critical to assessing the efficacy of isolating the virus infection and preventing further transmission in humans.

Fig.1 The Cytokine and Chemokine Responses Study in Animal Models of 2019-nCoV Infection.

Our Services for Cytokine and Chemokine Responses Study in Animal Models

The cytokine and chemokine responses study in animal models plays an important role in developing novel drugs for a range of disease therapy, especially for virus infection diseases. With the outbreak of SARS-CoV-2 in China, many intense research attempts have been made to develop an effective treatment or drugs in humans. Therefore, Creative Biolabs provides a wide spectrum of SARS-CoV-2 targeted drug discovery services for our worldwide customers. Meanwhile, many animal models of SARS-CoV-2 infection will be generated using different virus strains, virus dosages, as well as the route of virus inoculation to mimic the natural pathogenesis of SARS-CoV-2.

Creative Biolabs offers various animal models, such as mice, rats, dogs, and transgenic mice, to overcome the hurdle for investigating the cytokine and chemokine responses of SARS-CoV-2. For instance, animals with targeted expression of cytokines, such as interleukin (IL)-1, IL-2, IL-8, will be analyzed to study their function in SARS-CoV-2 infection. Additionally, we have also established a panel of pre-qualified cytokine and chemokine assays to avoid a number of additional diseases, including acute lung injury (ALI), and acute respiratory distress syndrome (ARDS), caused by SARS-CoV-2 targeted new drugs.

Creative Biolabs is dedicated to expanding cutting edge drug research across a range of applications. With our proven competencies and regulatory expertise, we are therefore confident in offering the best services targeting SARS-CoV-2. We can provide many flexible options, from which you can always find a better match for your particular project. If you are interested in our services, please contact us for more details.

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