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New Products for SARS-CoV-2 Omicron Variant
At present, SARS-CoV-2 has spread worldwide as an Omicron variant (B.1.1.529), which was first reported to the World Health Organization (WHO) from South Africa on 24 November 2021. WHO cautioned that the Omicron variant of SARS-CoV-2 has a very high risk of infection and apparently it has become the dominant strain of the virus circulating in the US and other parts of the world. Omicron multiplies around 70 times faster than the Delta variant, but may not be able to penetrate deep lung tissue. Therefore, Omicron infection is less fatal than Delta variants, and the hospitalization risk is reduced by 51%.
Mutations
Compared to previous variants, Omicron variant has a total of 60 mutations: 50 nonsynonymous mutations, 8 synonymous mutations, and 2 non-coding mutations. The variant has 32 mutations at the spike protein region, many of which have not been observed in other variants. The variant is characterized by 30 amino acids, three small deletions, and a small insertion in the spike protein compared to the original virus, wherein 15 is located in the receptor-binding domain. In addition, three mutations affect the Furin cleavage site, which adds SARS-CoV-2 infectivity. The mutations are shown below:
Fig.2 The genomic sequence of the Omicron variant. (Stanford HIVDB Team)
- Spike protein: A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
- ORF1ab: nsp3 (K38R, V1069I, Δ1265, L1266I, A1892T), nsp4 (T492I), nsp5 (P132H) nsp6 (Δ105-107, A189V), nsp12 (P323L), nsp14 (I42V)
- Envelope protein: T9I
- Membrane protein: D3G, Q19E, A63T
- Nucleocapsid protein: P13L, Δ31-33, R203K, G204R
Research into COVID-19 diagnostics, treatments, and vaccines, especially Omicron relevant study, will continue to dominate the 2022 innovation. Creative Biolabs perseveres to seek tools to assist this work. Below is the collection of Omicron products that have been added to the portfolio in recent months.
Shop Ready-to-Use Omicron Products by Type
Proteins Antibody Plasmid Pseudovirus Peptide
Recombinant Proteins for SARS-CoV-2 Omicron Variant (B.1.1.529)
| CAT | Product Name | Product Overview |
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Recombinant SARS-CoV-2 Omicron Nucleocapsid Protein [N-His] |
SARS-CoV-2, Recombinant Protein, Omicron Variants, variant B.1.1.529, P13L, E31del, R32del, S33del, R203K, G204R |
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Recombinant SARS-CoV-2 Omicron Nucleocapsid Protein [C-His] |
SARS-CoV-2, Recombinant Protein, Omicron Variants, variant B.1.1.529, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H |
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Recombinant SARS-CoV-2 Omicron Spike RBD Protein [His & AVI] Biotinylated |
SARS-CoV-2, Recombinant Protein, Omicron Variants, variant B.1.1.529, Spike RBD Protein, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H |
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Recombinant SARS-CoV-2 Omicron S1+S2 trimer Protein [ECD, His]-H |
SARS-CoV-2, Recombinant Protein, Omicron Variants, variant B.1.1.529, Spike S1+S2 trimer Protein, A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F |
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Recombinant SARS-CoV-2 Omicron Spike S1 Protein [His] |
SARS-CoV-2, Recombinant Protein, Omicron Variants, variant B.1.1.529, Spike S1 Protein, A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H |
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Recombinant SARS-CoV-2 Omicron S1+S2 trimer Protein [ECD, His]-B |
SARS-CoV-2, Recombinant Protein, Omicron Variants, variant B.1.1.529, Spike S1+S2 trimer Protein, A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F |
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Recombinant SARS-CoV-2 Omicron Spike S1 NTD Protein [His] |
SARS-CoV-2, Recombinant Protein, Omicron Variants, variant B.1.1.529, Spike S1 NTD Protein, A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I |
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Recombinant SARS-CoV-2 Omicron Spike RBD Protein [mFc Tag] |
SARS-CoV-2, Recombinant Protein, Omicron Variants, variant B.1.1.529, Spike RBD Protein, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H |
Antibodies for SARS-CoV-2 Omicron Variant (B.1.1.529)
| CAT | Product Name | Product Overview |
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SARS-CoV-2 Nucleocapsid Antibody (N338) |
SARS-CoV-2 Nucleocapsid Antibody (N338), specific for SARS-CoV-2 Nucleocapsid protein of wild type, delta variant, and omicron variant. |
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SARS-CoV-2 Nucleocapsid Antibody (N34) |
SARS-CoV-2 Nucleocapsid Antibody (N34), specific for SARS-CoV-2 Nucleocapsid protein of wild type, delta variant, and omicron variant. |
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SARS-CoV-2 Nucleocapsid Antibody (N66) |
SARS-CoV-2 Nucleocapsid Antibody (N66), specific for SARS-CoV-2 Nucleocapsid protein of wild type, delta variant, and omicron variant. |
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SARS-CoV-2 Nucleocapsid Antibody Cocktail |
SARS-CoV-2 Nucleocapsid Antibody Cocktail, specific for SARS-CoV-2 Nucleocapsid protein of wild type, delta variant, and omicron variant. |
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SARS-CoV-2 Neutralizing Antibody Standard (Omicron) |
SARS-CoV-2 (Omicron) Neutralizing Antibody Standard, can recognize and neutralize Wild-Type SARS-CoV-2 and five Variants of Concern (VOC) including Alpha, Beta, Gamma, Delta, and Omicron. |
S Gene Plasmids for SARS-CoV-2 Omicron Variant (B.1.1.529)
| CAT | Product Name | Product Overview |
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SARS-CoV-2 Omicron Strain S gene original_pUC57 |
SARS-CoV-2 Omicron Strain |
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SARS-CoV-2 Omicron Strain S gene Human codon_pUC57 |
SARS-CoV-2 Omicron Strain |
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SARS-CoV-2 Omicron Strain S gene original_pcDNA3.1(+) |
SARS-CoV-2 Omicron Strain |
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SARS-CoV-2 Omicron Strain S gene Human codon_pcDNA3.1(+) |
SARS-CoV-2 Omicron Strain |
Pseudovirus for SARS-CoV-2 Omicron Variant (B.1.1.529)
| CAT | Product Name | Product Overview |
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SARS-CoV-2 (Omicron) Spike-pseudovirus |
SARS-CoV-2 (Omicron) Spike-pseudovirus was prepared by co-transfecting 293T cells with an HIV-1 backbone plasmid and a plasmid containing the SARS-CoV-2 (Omicron) spike encoding gene. The packaged Spike-pseudovirus expresses full-length spike protein on the surface and carries a luciferase reporter gene, which can be used to infect cells that overexpress ACE2, and express luciferase in the cells to characterize infectivity of the virus. |
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SARS-CoV-2 B.1.1.529 (Omicron) Pseudovirus Neutralization Assay kit (Luciferase Reporter) |
Pseudovirus Neutralization Assay Kit for SARS-CoV-2 Omicron Variant (B.1.1.529) |
Peptide Library for SARS-CoV-2 Omicron Variant (B.1.1.529)
| CAT | Product Name | Product Overview |
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SARS-CoV-2 Spike Glycoprotein B.1.1.529-Omicron |
SARS-CoV-2 Spike Glycoprotein B.1.1.529-Omicron Peptide Pool is delivered in two sub-pools of 158 & 157 peptides derived from a peptide scan (15mers with 11 aa overlap) through the entire Spike glycoprotein of SARS-CoV-2 B.1.1.529 (Severe Acute Respiratory Syndrome-related coronavirus 2, Lineage B.1.1.529, South Africa, Omicron) covering the following mutations: A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, "EPE" insertion between 214R and 215D, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F. |
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For Research Use Only. We do not provide direct services or products for patients.
For Research Use Only. We do not provide direct services or products for patients.
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