Aptamers to SARS-CoV-2 Spike and N Protein
Since the outbreak of the new coronavirus pneumonia COVID-19 caused by the SARS-CoV-2, the disease has spread rapidly around the world. Considering the potential threat of the COVID-19 pandemic, scientists around the world have been working hard to understand this new virus and its pathophysiology to discover possible treatment options and find effective therapeutic drugs and vaccines. As an industry-leading-CRO, Creative Biolabs has also integrated our advanced technical resources to help researchers develop COVID-19 drugs.
The aptamer can bind to various target substances with high specificity and high selectivity. Although the sensitivity and specificity of traditional antigen-antibody reactions are good, enzyme-linked immunoassay plays an important role in the detection of various biomolecules, but proteins as probe molecules are susceptible to environmental factors such as pH and temperature. But as a probe molecule, protein is easily denatured by environmental factors such as pH and temperature, and the synthesis is expensive. The aptamer is composed of DNA or RNA (mainly DNA), which is smaller than the protein. After screening and enrichment by SELEX, it can have sensitivity comparable to antigen-antibody reaction, and it is easier to synthesize and has better stability. In the near future, aptamers are expected to replace enzyme-linked immunoreactions and become powerful weapons for the detection of various chemical molecules.
Working around the clock, we have developed a series of aptamers with high affinity for SARS-CoV-2 spike protein S1 and N protein. Our aptamers have been verified to specifically bind SARS-CoV-2, which can be used to quickly establish effective detection methods and may also be used for the treatment of COVID-19. If you would like to know more information on our COVID-19 aptamers and explore how aptamers can help in your research, please feel free to contact us.
We currently provide below aptamers, and ensure that they can bind to the target protein in SPR detection.
|Target||CAT#||PRODUCT NAME||Affinity (Kd)|
|Spike S1 protein||VAp-Lsx001||SARS-CoV-2 Spike S1 Aptamer A1-56nt||7.78 nM|
|VAp-Lsx002||SARS-CoV-2 Spike S1 Aptamer A1-56nt (thiol)||7.78 nM|
|VAp-Lsx003||SARS-CoV-2 Spike S1 Aptamer A1-56nt (amino)||7.78 nM|
|VAp-Lsx004||SARS-CoV-2 Spike S1 Aptamer A1-56nt (biotin)||7.78 nM|
|VAp-Lsx005||SARS-CoV-2 Spike S1 Aptamer A2-56nt||2.97 nM|
|VAp-Lsx006||SARS-CoV-2 Spike S1 Aptamer A2-56nt (thiol)||2.97 nM|
|VAp-Lsx007||SARS-CoV-2 Spike S1 Aptamer A2-56nt (amino)||2.97 nM|
|VAp-Lsx008||SARS-CoV-2 Spike S1 Aptamer A2-56nt (biotin)||2.97 nM|
|VAp-Lsx009||SARS-CoV-2 Spike S1 Aptamer A1-24nt||4.55 nM|
|VAp-Lsx010||SARS-CoV-2 Spike S1 Aptamer A1-24nt (thiol)||4.55 nM|
|VAp-Lsx011||SARS-CoV-2 Spike S1 Aptamer A1-24nt (amino)||4.55 nM|
|VAp-Lsx012||SARS-CoV-2 Spike S1 Aptamer A1-24nt (biotin)||4.55 nM|
|VAp-Lsx013||SARS-CoV-2 Spike S1 Aptamer A2-27nt||9.53 nM|
|VAp-Lsx014||SARS-CoV-2 Spike S1 Aptamer A2-27nt (thiol)||9.53 nM|
|VAp-Lsx015||SARS-CoV-2 Spike S1 Aptamer A2-27nt (amino)||9.53 nM|
|VAp-Lsx016||SARS-CoV-2 Spike S1 Aptamer A2-27nt (biotin)||9.53 nM|
|N protein||VAp-Lsx017||SARS-CoV-2 N Aptamer N1-58nt||3.28 nM|
|VAp-Lsx018||SARS-CoV-2 N Aptamer N1-58nt (thiol)||3.28 nM|
|VAp-Lsx019||SARS-CoV-2 N Aptamer N1-58nt (amino)||3.28 nM|
|VAp-Lsx020||SARS-CoV-2 N Aptamer N1-58nt (biotin)||3.28 nM|
|VAp-Lsx021||SARS-CoV-2 N Aptamer N2-58nt||1.91 nM|
|VAp-Lsx022||SARS-CoV-2 N Aptamer N2-58nt (thiol)||1.91 nM|
|VAp-Lsx023||SARS-CoV-2 N Aptamer N2-58nt (amino)||1.91 nM|
|VAp-Lsx024||SARS-CoV-2 N Aptamer N2-58nt (biotin)||1.91 nM|
|VAp-Lsx025||SARS-CoV-2 N Aptamer N3-58nt||7.71 nM|
|VAp-Lsx026||SARS-CoV-2 N Aptamer N3-58nt (thiol)||7.71 nM|
|VAp-Lsx027||SARS-CoV-2 N Aptamer N3-58nt (amino)||7.71 nM|
|VAp-Lsx028||SARS-CoV-2 N Aptamer N3-58nt (biotin)||7.71 nM|
|VAp-Lsx029||SARS-CoV-2 N Aptamer N4-58nt||5.86 nM|
|VAp-Lsx030||SARS-CoV-2 N Aptamer N4-58nt (thiol)||5.86 nM|
|VAp-Lsx031||SARS-CoV-2 N Aptamer N4-58nt (amino)||5.86 nM|
|VAp-Lsx032||SARS-CoV-2 N Aptamer N4-58nt (biotin)||5.86 nM|
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