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Product Overview
2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol, potassium salt (DUP-753), Angiotensin II Receptor Antagonist
Target
SARS-CoV-2
Molecular Formula
C22H22ClN6O·K
Molecular Weight
461.0 g/mol
Purity
>99% by HPLC
Storage
Store at 4°C.
Introduction
Losartan potassium is an active, nonpeptide angiotensin II (AII) receptor antagonist, and has high affinity and selectivity against to the AII subtype 1 receptor. it is currently being used as a treatment option against hypertension. SARS-CoV-2 infects the human cells by its Spike (S) protein binding to the human ACE2 cell receptor. Renin-Angiotensin-Aldosterone System Inhibitors such losartan are being investigated for their unconventional role in inhibiting SARS-CoV-2/ACE2 fusions at the moment as a possible treatment option to solve the COVID-19 crisis.