[2H5]-Desethylchloroquine diphosphate salt (CAT#: Vinh-Wyb032)
For Research Use Only. We do not provide direct services or products for patients.
Molecular Formula: C16H22ClN3.2H3PO4 or C16H17D5ClN3.2H3PO4; Molecular Weight: 492.84 g.mol-1
C16H22ClN3.2H3PO4 or C16H17D5ClN3.2H3PO4
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs). Chloroquine can also combine with heme to form a toxic heme-Chloroquine complex, which can inhibit vacuolar phospholipase, increase vacuolar pH, inhibit vacuolar protease and heme polymerase activity, thereby inhibiting the breakdown of trophozoite hemoglobin. As a chemotherapeutic agent for clinical treatment of malaria. Chloroquine can bind DNA and inhibit DNA replication and RNA synthesis to cause cell death.