[2H5]-Hydroxychloroquine dioxalate salt (CAT#: Vinh-Wyb026)
For Research Use Only. We do not provide direct services or products for patients.
Molecular Formula: C18H26ClN3O.2C2H2O4 or C18H21D5ClN3O.2C2H2O4; Molecular Weight: 520.97 g.mol-1
Unlabelled 118-42-3(free base)
C18H26ClN3O.2C2H2O4 or C18H21D5ClN3O.2C2H2O4
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs). Chloroquine can also combine with heme to form a toxic heme-Chloroquine complex, which can inhibit vacuolar phospholipase, increase vacuolar pH, inhibit vacuolar protease and heme polymerase activity, thereby inhibiting the breakdown of trophozoite hemoglobin. As a chemotherapeutic agent for clinical treatment of malaria. Chloroquine can bind DNA and inhibit DNA replication and RNA synthesis to cause cell death.