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Molecular Formula: C18H26ClN3O.H2SO4 or C18H21D5ClN3O.H2SO4; Molecular Weight: 438.98 g.mol-1
C18H26ClN3O.H2SO4 or C18H21D5ClN3O.H2SO4
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs). Chloroquine can also combine with heme to form a toxic heme-Chloroquine complex, which can inhibit vacuolar phospholipase, increase vacuolar pH, inhibit vacuolar protease and heme polymerase activity, thereby inhibiting the breakdown of trophozoite hemoglobin. As a chemotherapeutic agent for clinical treatment of malaria. Chloroquine can bind DNA and inhibit DNA replication and RNA synthesis to cause cell death.