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Molecular Formula: C37H48N4O5 or C37H42D6N4O5; Molecular Weight: 634.84 g.mol-1
C37H48N4O5 or C37H42D6N4O5
Lopinavir is a potent HIV protease inhibitor with a Ki of 1.3pM. Lopinavir can block the division of Gag-Pol polyprotein, resulting in the production of immature, non-infectious virus particles. In vitro antiviral activity experiments showed that lopinavir showed in vitro antiviral activity against laboratory HIV and clinical HIV isolates in acutely infected lymphoblastoid cell lines and peripheral blood lymphocytes. In addition, lopinavir has a preventive effect on cervical cancer caused by human papillomavirus (HPV).