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Product Overview
Human ACE2, Rabbit anti-ACE2 IgG Antibody, purity>95%.
Target
ACE2
Source
Rabbit
Clonality
PAb
Immunogen
Recombinant human ACE2 protein (aa 395-638)
Specificity
Human ACE2
Type
Antibody
Conjugate
Unconjugated
Purification
Protein G
Form
Liquid
Buffer Solution
50% Glycerol, 0.01 M PBS, pH 7.4.
Applications
Used for ELISA, IHC, IF.
Storage
Store at -20°C or -80°C
Introduction
Angiotensin-converting enzyme 2 (ACE2) regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Abundant evidence demonstrated that ACE2 plays physiological and pathological role in the cardiovascular, renal and respiratory systems as well as blood pressure control. Ang-(1-7) is considered as major biologically active product of ACE2. ACE2's physiological role has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the SARS-CoV (severe acute respiratory syndrome coronavirus). Moreover, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis.