Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). The compound is an effective treatment against high blood pressure and a few types of congestive heart failures. SARS-CoV-2 infects the human cells by using its Spike (S) protein to fuse with the human ACE2 cell receptor. Renin-Angiotensin-Aldosterone System Inhibitors such as Captopril are being investigated for their unconventional therapeutic role in inhibiting SARS-CoV-2/ACE2 fusions as a possible treatment option to solve the COVID-19 crisis.