[2H5]-Desethylchloroquine dioxalate salt (CAT#: Vinh-Wyb033)
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Vinh-Wyb033
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Product Overview
Molecular Formula: C16H22ClN3.2C2H2O4 or C16H17D5ClN3.2C2H2O4; Molecular Weight: 476.92 g.mol-1
Target
SARS-CoV-2
Molecular Formula
C16H22ClN3.2C2H2O4 or C16H17D5ClN3.2C2H2O4
Molecular Weight
476.92 g.mol-1
Purity
>98%
Introduction
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs). Chloroquine can also combine with heme to form a toxic heme-Chloroquine complex, which can inhibit vacuolar phospholipase, increase vacuolar pH, inhibit vacuolar protease and heme polymerase activity, thereby inhibiting the breakdown of trophozoite hemoglobin. As a chemotherapeutic agent for clinical treatment of malaria. Chloroquine can bind DNA and inhibit DNA replication and RNA synthesis to cause cell death.