Adenosine Analogue for the Treatment of SARS-CoV-2
Studies indicated that adenosine analogues revealed high efficacy as RNA polymerase inhibitors. Thus, the therapeutic potential of adenosine analogues and conjugates has been extensively studied in recent years. Creative Biolabs provides chemical synthesis services and specializes in custom synthesis. Specifically, we offer our customers a broad range of adenosine analogues development services, from the first-time synthesis of complex and commercially not available compounds to the optimization of synthetic routes and biophysical characterization, assessment and modeling of the product.
Adenosine is a nucleoside signaling molecule that participates in numerous processes in the human body. The main role of adenosine is to maintain homeostasis and its neuromodulatory action. Adenosine acts through the adenosine receptor (AR), A1AR, A2AAR, A2BAR, and A3AR. Besides being the ligand for the ARs, adenosine is involved in key biochemical processes. For instance, RNA requires purine nucleoside substrates for its synthesis. Adenosine is a part of ATP and cAMP. Therefore, adenosine has been an important target molecule for the development of new medicines against numerous diseases. However, the clinical utility of adenosine is restricted due to its short half-life in blood and non-selectivity towards different receptor subtypes. Since receptor selectivity is highly important to minimize side effects and achieve the desired effects, numerous adenosine analogues have been synthesized.
Fig.1 Adenosine structure. (Samsel, 2011)
At Creative Biolabs, many achievements have been made in developing compounds containing the adenosine moiety that are considered potential drugs. Besides AR agonists with good selectivity and efficacy, binary drugs are achieved by tethering adenosine to a ligand for a different domain or type of receptor. The third noteworthy group is adenosine analogues. For example:
Fig.2 Guanosine served as the starting material in the synthesis of 2-chloro-N6-substituted adenosine analogues. (Ha, 1997)
We supply our clients with custom-made adenosine analogues molecules for their SARS-CoV-2 drug research. Our custom drug discovery services including but not limited to:
At Creative Biolabs, teams of experienced organic chemists can produce a variety of adenosine analogues molecules for your drug discovery research. Please feel free to contact us for more information.
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