In Vitro Systems for SARS-CoV-2 Drug Discovery

Creative Biolabs is a leading service provider that focuses on drug discovery. In response to the SARS-CoV-2 infection, we are pleased to use our extensive experience and advanced platform to offer the best service and the most qualified products to satisfy each demand from our customers.

Introduction of SARS-CoV-2

SARS-CoV-2, also known as 2019 Novel Coronavirus, is a new coronavirus that has been spreading in China and multiple other countries. Similar to the well-known severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), its classical symptoms include fever, cough, and shortness of breath. It has been reported that SARS-CoV-2 can spread people-to-people via respiratory droplets from the patients' coughs or sneezes. In order to avoid this serious situation posed by SARS-CoV-2, Creative Biolabs provides a series of drug discovery services.

2019 Novel Coronavirus Fig.1 2019 Novel Coronavirus (2019-nCoV).

In Vitro Systems against SARS-CoV-2

In the pharmaceutical field, drug discovery is a complicated process that new candidates are discovered. This process also requires the in vitro and in vivo tests for the activity in the disease model of choice. For in vitro antiviral drug discovery, Creative Biolabs now provides both reverse genetics systems and cell-based systems for our customers all over the world.

Reverse Genetics Systems

Reverse genetics systems refer to the methods in molecular genetics that have been used to understand the gene function via the analysis of phenotypic effects of specific nucleic acid sequences.

Reverse genetics systems provide key critical insights into viral replication and pathogenesis for manipulating viral genomes. Through direct gene modification and attenuation, these systems facilitate the development of novel vaccines and viral vectors for gene therapy.

Reverse genetics systems for the rescue of arenaviruses from cDNA. Fig.2 Reverse genetics systems for the rescue of arenaviruses from cDNA.

Cell-based Systems

Cell-based systems refer to the mathematical models which represent biological cells as discrete entities. The cell-based systems always describe individual behavior at the cell level, including cell proliferation, cell migration, and cell apoptosis. In this case, cell-based systems might be a wonderful tool to study the influence of these behaviors on how tissues are organized in space and time.

In recent years, cell-based systems have been used solely or in combination with animal studies for the drug mechanism of action (MOA) researches. In addition, these systems based on known mechanisms might be used as a novel screening platform for antiviral drug discovery.

SARS-CoV-2 Spike-pseudovirus Based Neutralization Assay

Pseudoviruses do not contain viral nucleic acids and cannot be replicated in the human body, but contain the necessary components for viral infection and entry into cells. Therefore, they can be used as an effective replacement of live viruses to assess the neutralizing activity of drugs or vaccines under the premise of ensuring safety. Creative Biolabs packages a pseudovirus with the SARS-CoV-2 spike protein on the surface and a luciferase reporter gene inside, and uses the proprietary ACE2-CHO Clonal Cell-expressing the ACE-2 receptor as the target cell, which can effectively asses the neutralizing activity of the COVID-19 vaccine or drug.

Creative Biolabs is one of the well-recognized experts who are professional in applying advanced drug discovery platforms for a broad range of project objectives. If you are interested in our services, please do not hesitate to contact us for more details.

For Research Use Only. We do not provide services or products directly for patients.

Other Preclinical Research for SARS-CoV-2:

Online Inquiry For Research Use Only. We do not provide services or products directly for patients
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