The receptor for IP-10 (interferon-inducible protein-10) is CXCR3. IP-10 is mainly derived from monocytes / K phagocytes and T lymphocytes, and its variants can enhance receptor activity. IP-10 is closely related to CXCLll / I-IAC and can be converted into each other. During the inflammatory reaction such as viral infection, the concentration of IP-10 in various systems (such as nervous system, liver and spleen, etc.) may increase to varying degrees, and also significantly increase in transplant rejection. Given its unique role, IP-10 targeted therapy is expected to prevent the clinical progression of certain diseases.
Interferon gamma induced factor MOB1, chemokine (C-X-C motif) ligand 10, CXCL10, Interferon gamma induced protein 10, interferon-inducible protein 10, IP-10