Human ACE2 Inhibitor Screening Kit (CAT#: VCok-Wyb023)

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VCok-Wyb023
For Research Use Only. We do not provide direct services or products for patients.

  • Product Overview
  • The Human ACE2 Inhibitor Screening Kit utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. And can be used to screen for potent inhibitors of ACE2 activity in simple and high-throughput format.
  • Target
  • SARS-CoV-2
  • Specificity
  • Human ACE2
  • Contents
  • ACE2 Assay Buffer; ACE2 Dilution Buffer; ACE2 Enzyme; ACE2 Substrate; ACE2 Inhibitor.
  • Testing
  • ACE2
  • Testing Principle
  • Fluorescence
  • Applications
  • Screening/characterizing inhibitors/ligands of ACE2
  • Storage
  • Store at -20°C
  • Introduction
  • Angiotensin-converting enzyme 2 (ACE2) regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Abundant evidence demonstrated that ACE2 plays physiological and pathological role in the cardiovascular, renal and respiratory systems as well as blood pressure control. Ang-(1-7) is considered as major biologically active product of ACE2. ACE2's physiological role has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the SARS-CoV (severe acute respiratory syndrome coronavirus). Moreover, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis.
  • Alternative Names
  • Angiotensin-converting enzyme 2; ACE2)

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